Molecular Diversity 2012-08-01

Regioselective multi-component synthesis of 1H-pyrazolo[3,4-d]pyrimidine-6(7H)-thiones.

Shirin Safaei, Iraj Mohammadpoor-Baltork, Ahmad Reza Khosropour, Majid Moghadam, Shahram Tangestaninejad, Valiollah Mirkhani

Index: Mol. Divers. 16(3) , 591-600, (2012)

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Abstract

A variety of pyrazolo[3,4-d]pyrimidine-6(7H)-thione derivatives were easily synthesized with a novel, simple, efficient, and regioselective method via three-component condensation reaction of 5-methyl-1H-pyrazol-3-amine, arylisothiocyanates, and aldehydes in the presence of catalytic amount of p-toluenesulfonic acid (p-TSA) in 1-butyl-3-methylimidazolium bromide ionic liquid with excellent yields and short reaction times.

Related Compounds

  • Sodium toluene-4-s...
  • TOLUENE-4-SUL...

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