Journal of Pharmacy and Pharmacology 1988-02-01

Inhibition of the cataleptic effect of tetrahydrocannabinol by other constituents of Cannabis sativa L.

E A Formukong, A T Evans, F J Evans

Index: J. Pharm. Pharmacol. 40(2) , 132-4, (1988)

Full Text: HTML

Abstract

Tetrahydrocannabinol (THC) induced catalepsy in mice, whereas a cannabis oil (6.68% w/w THC), four cannabinoids and a synthetic mixture did not. Cannabinol (CBN) and olivetol inhibited THC-induced catalepsy in the mornings and the evenings, but cannabidiol (CBD) exhibited this effect only in the evenings. A combination of CBN and CBD inhibited THC-induced catalepsy equal to that of CBN alone in the mornings, but this inhibition was greater than that produced by CBN alone in the evenings.

Related Compounds

  • Olivetol

Related Articles:

¹H NMR and HPLC/DAD for Cannabis sativa L. chemotype distinction, extract profiling and specification.

2015-08-01

[Talanta 140 , 150-65, (2015)]

Preparation and evaluation of molecularly imprinted polymer of olivetol for solid phase extraction.

2013-06-01

[Se Pu 31(6) , 587-95, (2013)]

Cannabidiol is a potent inhibitor of the catalytic activity of cytochrome P450 2C19.

2013-01-01

[Drug Metab. Pharmacokinet. 28(4) , 332-8, (2013)]

Biotransformation of olivetol by Syncephalastrum racemosum.

1984-01-01

[J. Nat. Prod. 47(5) , 828-34, (1984)]

Characterization of olivetol synthase, a polyketide synthase putatively involved in cannabinoid biosynthetic pathway.

2009-06-18

[FEBS Lett. 583(12) , 2061-6, (2009)]

More Articles...