Acta Biomaterialia 2013-02-01

Volume change of double cross-linked poly(aspartic acid) hydrogels induced by cleavage of one of the crosslinks.

Miklos Zrinyi, Tamas Gyenes, David Juriga, Ji-Heung Kim

Index: Acta Biomater. 9(2) , 5122-31, (2013)

Full Text: HTML

Abstract

In the present paper we report for the first time the development of redox-responsive biocompatible polymer gels. Double cross-linked poly(aspartic acid) hydrogels were prepared using two different cross-linking agents simultaneously. One of the cross-linkers was diaminobutane (DAB), the other cystamine (CYS). The relative amounts of DAB and CYS molecules were varied over a wide range while the total amount of cross-linker molecules (DAB+CYS) was kept constant. DAB provides stable cross-links, whereas CYS contains disulfide bonds, which can be broken by reduction. The cleavage of disulfide cross-links results in enhanced swelling and a significant decrease in the elastic modulus of the gels. These novel types of stimuli-responsive gels are promising candidates for new swelling controlled release matrices.Copyright © 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

Related Compounds

  • Cystamine dihydroc...

Related Articles:

Curcumin delivery from poly(acrylic acid-co-methyl methacrylate) hollow microparticles prevents dopamine-induced toxicity in rat brain synaptosomes.

2015-01-01

[Int. J. Pharm. 486 , 259-67, (2015)]

ROP and ATRP Fabricated Dual Targeted Redox Sensitive Polymersomes Based on pPEGMA-PCL-ss-PCL-pPEGMA Triblock Copolymers for Breast Cancer Therapeutics.

2015-05-06

[ACS Appl. Mater. Interfaces 7 , 9211-27, (2015)]

Glycopolymer micelles with reducible ionic cores for hepatocytes-targeting delivery of DOX.

2013-01-30

[Int. J. Pharm. 441(1-2) , 170-80, (2013)]

Gold nanoparticles immobilized hydrophilic monoliths with variable functional modification for highly selective enrichment and on-line deglycosylation of glycopeptides.

2015-11-05

[Anal. Chim. Acta 900 , 83-9, (2015)]

Cys-pair reporters detect a constrained trigger loop in a paused RNA polymerase.

2013-06-27

[Mol. Cell. 50(6) , 882-93, (2013)]

More Articles...