Biomaterials 2013-06-01

An injectable cell penetrable nano-polyplex hydrogel for localized siRNA delivery.

Young-Min Kim, Mi-Ran Park, Soo-Chang Song

Index: Biomaterials 34(18) , 4493-500, (2013)

Full Text: HTML

Abstract

An approach for application of cell penetration to selective small interference RNA (siRNA) localized delivery system, cell penetrable nano-polyplex assembled hydrogel system, is presented. The cell penetrable nano-polyplex assembled hydrogelisprepared by protamine conjugation to poly(organophos-phazene) and inducement of nano-polyplexes with siRNAs. After an injection of cell penetrable nano-polyplex solution into the body, it turns into a gel due to thermosensitivity of poly(organo- phosphazene). The gel maintains up to 4 weeks and the released 30 nm-sized nano-polyplexes from the gel induces highly effective siRNA delivery due to cell penetration. Accordingly, the new system shows a high gene silencing efficiency on only the target site in long-term with a single injection.Copyright © 2013 Elsevier Ltd. All rights reserved.

Related Compounds

  • Fluorescein isothi...
  • fluorescein 5-isot...
  • Poly(ethylene glyc...

Related Articles:

Imaging of a clinically relevant stroke model: glucose hypermetabolism revisited.

2015-03-01

[Stroke 46(3) , 835-42, (2015)]

Surface modifications of silica nanoparticles are crucial for their inert versus proinflammatory and immunomodulatory properties.

2014-01-01

[Int. J. Nanomedicine 9 , 2815-32, (2014)]

Uptake of neutrophil-derived Ym1 protein distinguishes wound macrophages in the absence of interleukin-4 signaling in murine wound healing.

2014-12-01

[Am. J. Pathol. 184(12) , 3249-61, (2014)]

Brain pericyte-derived soluble factors enhance insulin sensitivity in GT1-7 hypothalamic neurons.

2015-02-20

[Biochem. Biophys. Res. Commun. 457(4) , 532-7, (2015)]

Evaluation of a dental pulp-derived cell sheet cultured on amniotic membrane substrate.

2015-01-01

[Biomed Mater Eng 25(2) , 203-12, (2015)]

More Articles...