Organic Process Research & Development

Synthesis of enantiopure Fmoc-α-methylvaline

L Shu, P Wang

Index: Shu, Lianhe; Wang, Ping Organic Process Research and Development, 2008 , vol. 12, # 2 p. 298 - 300

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Citation Number: 7

Abstract

An efficient synthesis of enantiopure Fmoc-α-methylvaline has been developed. The racemate was prepared in two steps from 3-methyl-2-butanone and was resolved using a chiral amine,(S)-1, 2, 3, 4-tetrahydro-1-naphthylamine to give the desired, enantiopure S- isomer in 23% overall yield.

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