Journal of Natural Products 2001-11-01

Inhibition of Mycobacterium tuberculosis growth by saringosterol from Lessonia nigrescens.

G A Wächter, S G Franzblau, G Montenegro, J J Hoffmann, W M Maiese, B N Timmermann

Index: J. Nat. Prod. 64(11) , 1463-4, (2001)

Full Text: HTML

Abstract

Assay-guided fractionation of an antitubercular extract obtained from Lessonia nigrescens yielded the phytosterol saringosterol as its active component. No appreciable toxicity against Vero cells was observed for this compound. Saringosterol was also synthesized by oxidation of fucosterol. The MIC values for antitubercular activity of saringosterol and its 24S and 24R epimers were determined as 0.25, 1, and 0.125 microg/mL.

Related Compounds

  • Fucosterol

Related Articles:

Kinetics and molecular docking studies of an anti-diabetic complication inhibitor fucosterol from edible brown algae Eisenia bicyclis and Ecklonia stolonifera.

2013-10-25

[Chem. Biol. Interact. 206(1) , 55-62, (2013)]

The effect of traditional stir-frying process on hydrophilic and lipophilic antioxidant capacities of pine nut kernels.

2015-01-01

[Int. J. Food Sci. Nutr. 66 , 873-80, (2015)]

Visible fibrinolysis by endothelial cells: effect of vitamins and sterols.

1986-12-01

[Biosci. Rep. 6(12) , 1029-33, (1986)]

Biosynthesis of the irregular monoterpene artemisia ketone, the sesquiterpene germacrene D and other isoprenoids in Tanacetum vulgare L. (Asteraceae).

2004-09-01

[Phytochemistry 65(17) , 2463-70, (2004)]

Isolation of two new C30 sterols, (24E)-24-N-propylidenecholesterol and 24 epsilon-N-propylcholesterol, from a cultured marine Chrysophyte.

1980-02-01

[Steroids 35(2) , 219-31, (1980)]

More Articles...