N-aminoimidazole derivatives inhibiting retroviral replication via a yet unidentified mode of action

…, A Van Aerschot, M Witvrouw, Z Debyser…

Index: Lagoja, Irene M.; Pannecouque, Christophe; Van Aerschot, Arthur; Witvrouw, Myriam; Debyser, Zeger; Balzarini, Jan; Herdewijn, Piet; De Clercq, Erik Journal of Medicinal Chemistry, 2003 , vol. 46, # 8 p. 1546 - 1553

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Citation Number: 51

Abstract

The synthesis of a series of N-aminoimidazoles (NAIMs) with an uncommon spectrum of antiretroviral activity is described. From a group of 60 closely related molecules, we were able to subdivide the molecules in different groups based on their anti-HIV and anti-SIV activity in vitro:(i) molecules acting on a new, immediate postintegration step,(ii) molecules acting on both postintegration and HIV-1 reverse transcriptase (RT) as NNRTI, and (iii) ...

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