Tryptamine derivatives as novel non-nucleosidic inhibitors against hepatitis B virus

…, GF Wang, WH Duan, SY Yao, JP Zuo, CH Tan…

Index: Qu, Shi-Jin; Wang, Gui-Feng; Duan, Wen-Hu; Yao, Shan-Yan; Zuo, Jian-Ping; Tan, Chang-Heng; Zhu, Da-Yuan Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 10 p. 3120 - 3127

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Citation Number: 16

Abstract

Abstract A series of tryptamine derivatives were synthesized and evaluated for their anti- hepatitis B virus (HBV) activity and cytotoxicity in the HepG2. 2.15 cell line. The preliminary SAR was discussed. Compounds 2e and 4a showed potent antiviral activity (IC 50= 0.4 and< 1 μM, respectively) and low cytotoxicity (CC 50= 40.6 and> 25 μM, respectively).