Tetrahedron letters

Improved large-scale synthesis of phenylisoserine and the taxol C-13 side chain

MV Voronkov, AV Gontcharov, ZM Wang

Index: Voronkov, Michael V.; Gontcharov, Alexander V.; Wang, Zhi-Min Tetrahedron Letters, 2003 , vol. 44, # 2 p. 407 - 409

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Citation Number: 19

Abstract

Dihydrodihydroxycinnamic acids and their esters react with acetonitrile or benzonitrile in the presence of sulfuric acid to afford the corresponding syn-β-amino-α-hydroxypropionic acid derivatives. High yields and diastereoselectivity of this transformation allows preparation of various phenylisoserine derivatives on a practical scale.

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