Efficient and practical asymmetric synthesis of the taxol C-13 side chain, N-benzoyl-(2R, 3S)-3-phenylisoserine, and its analogs via chiral 3-hydroxy-4-aryl-. beta.- …

I Ojima, I Habus, M Zhao, GI Georg…

Index: Ojima, Iwao; Habus, Ivan; Zhao, Mangzhu; Georg, Gunda I.; Jayasinghe, Lalith R. Journal of Organic Chemistry, 1991 , vol. 56, # 5 p. 1681 - 1683

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Citation Number: 203

Abstract

Summary: A highly efficient chiral ester enolate-imine condensation giving 3-hydroxy-4aryl- j3-1actams with> 96% ee is successfully applied to the asymmetric synthesis of the enantiomerically pure taxol C-13 side chain, N-benzoyl-(2R, 3S)-3-phenylisoserine, and ib r analogues.

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