Tetrahedron Letters

Synthesis of some analogues of (±) gelliusine F,(±) gelliusine E, and total synthesis of 2, 2-di (6′-bromo-3′-indolyl) ethylamine

PS Naidu, PJ Bhuyan

Index: Seetham Naidu; Bhuyan, Pulak J. Tetrahedron Letters, 2012 , vol. 53, # 4 p. 426 - 428

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Citation Number: 14

Abstract

3,3′-Diindolylmethane (DIM) is a major digestive product of indole-3-methanol, a potential anti-cancer component of cruciferous vegetables. 1 It is a potent activator of the immune response system in vivo. 2 It activates and potentiates interferon-gamma signalling in human cells 3 and its use as supplement in human increases the 2-hydroxylation of oestrogen metabolites. 4 3,3′-Diindolylmethane reduces the growth of breast cancer cells by 95% 5 and exhibits ...

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