Journal of Combinatorial Chemistry 2010-01-01

Oriented synthesis and in vitro anticancer activity of biquinazoline-2,2'-diones.

Guolan Dou, Daqing Shi, Yonghai Li

Index: J. Comb. Chem. 12(1) , 195-9, (2010)

Full Text: HTML

Abstract

The synthesis of a series of biquinazoline-2,2'-diones starting from o-nitrobenzaldehydes, anilines, and triphosgene is presented. This general approach features a novel and easy way for access to the target products. The mechanistic course of the reaction suggests the involvement of reduction, coupling, and cyclization by one-pot. These compounds were also investigated in vitro for anticancer activity, and some were found to have good anticancer activity.

Related Compounds

  • Triphosgene
  • 2-Nitrobenzaldehyd...

Related Articles:

Multi-modal transfection agent based on monodisperse magnetic nanoparticles for stem cell gene delivery and tracking.

2014-08-01

[Biomaterials 35(25) , 7239-47, (2014)]

Poly(anhydride-ester) and poly(N-vinyl-2-pyrrolidone) blends: salicylic acid-releasing blends with hydrogel-like properties that reduce inflammation.

2015-03-01

[Macromol. Biosci. 15(3) , 342-50, (2015)]

Ultrasound-Triggered Phase-Transition Cationic Nanodroplets for Enhanced Gene Delivery.

2015-06-24

[ACS Appl. Mater. Interfaces 7 , 13524-37, (2015)]

Tumor-preferential sustained drug release enhances antitumor activity of block copolymer micelles.

2014-08-01

[J. Drug Target. 22(7) , 619-28, (2014)]

Polyethylenimine derivate conjugated with RGD-TAT-NLS as a novel gene vector.

2014-01-01

[Biomed Mater Eng 24(6) , 1933-9, (2014)]

More Articles...