Synthesis

Aminomethylation of Functionalized Organozinc Reagents and Grignard Reagents Using Immonium Trifluoroacetates

N Millot, C Piazza, S Avolio, P Knochel

Index: Millot, Nicolas; Piazza, Claudia; Avolio, Salvatore; Knochel, Paul Synthesis, 2000 , # 7 p. 941 - 948

Full Text: HTML

Citation Number: 33

Abstract

Abstract: New immonium trifluoroacetates 1 and 2 react readily with functionalized organozinc or magnesium reagents leading to the corresponding aminomethylated products of type 5 and 7. The resulting bis-allylamines were deallylated leading to primary amines. Key words: organometallic reagents, zinc, magnesium, aminomethylation, primary amines, deprotection