Synthesis and antihistaminic activity of 1??[(4??substituted??l, 2, 3??thiadiazol??5??yl) arylmethyl]??4??methylpiperazines

A Shafiee, M Mohamadpour, F Abtahi…

Index: Shafiee; Mohamadpour; Abtahi; Khoyi Journal of Pharmaceutical Sciences, 1981 , vol. 70, # 5 p. 510 - 513

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Citation Number: 8

Abstract

Abstract Starting with readily available aryl 4-substituted-1, 2, 3-thiadiazol-5-yl ketones, a series of 1-[(4-substituted-1, 2, 3-thiadiazol-5-yl) arylmethyl]-4-methylpiperazines was synthesized and tested for antihistaminic and anticholinergic activities. Four compounds were potent antihistamines, and two of these compounds displayed moderate anticholinergic activity.