Bioorganic & medicinal chemistry letters

Synthesis and bioactivities of novel 4, 5, 6, 7-Tetrahydrothieno [2, 3-c] pyridines as inhibitors of tumor necrosis factor-α (TNF-α) production

M Fujita, T Seki, H Inada, N Ikeda

Index: Fujita, Masakazu; Seki, Taketsugu; Inada, Haruaki; Ikeda, Naoko Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 12 p. 1607 - 1611

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Citation Number: 13

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... Novel 4,5,6,7-tetrahydrothieno[2,3-c]pyridine derivatives were synthesized and evaluated for their abilities to inhibit lipopolysaccharide (LPS)-stimulated production of TNF-α in rat whole blood. Several of these compounds exhibited potent inhibitory activity. ... Novel 4,5,6,7-tetrahydrothieno[ ...

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