Synlett

First synthesis of marine alkaloid (±)-bengacarboline

A Pouilhes, Y Langlois, A Chiaroni

Index: Pouilhes, Annie; Langlois, Yves; Chiaroni, Angele Synlett, 2003 , # 10 p. 1488 - 1490

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Citation Number: 14

Abstract

Bengacarboline 1 a marine alkaloid, extracted from the Fijian ascidian Didemnum sp. has been described six years ago by Ireland and co-workers. [1] This alkaloid is an inhibitor of topoisomerase II and displays an in vitro toxicity with a mean of 0.9 µg/mL (0.4 µmol/mL) toward 26 cell line tumor panel. The structure of bengacarboline 1 is characterized by a tetrahydro-β-carboline core linked at C1 with a tryptamine and an indol units. Absolute configuration of the quaternary center ...