Bioorganic & medicinal chemistry letters

Chemically-tagged Mitsunobu reagents for use in solution-phase chemical library synthesis

GW Starkey, JJ Parlow, DL Flynn

Index: Starkey, Gale W.; Parlow, John J.; Flynn, Daniel L. Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 17 p. 2385 - 2390

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Citation Number: 57

Abstract

A general method for high-throughput product purification of Mitsunobu reactions is described. Tagged phosphine and azodicarboxylate reagents are used to synthesize individual library members in solution-phase. Workup and purification are easily accomplished by post-reaction sequestration of the tagged reagents and reagent byproducts by a complementary functionalized ion exchange resin. The reagents are utilized in a 3 ...