Influence of supercritical CO(2) pressurization on the phase behavior of mixed cholesteryl esters.

Zhen Huang, Mei Feng, Junfeng Su, Yuhua Guo, Tie-Yan Liu, Yee C Chiew

Index: Int. J. Pharm. 397(1-2) , 130-5, (2010)

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Abstract

Evidences indicating the presence of phase transformations in the mixed cholesteryl benzoate (CBE) and cholesteryl butyrate (CBU) under the supercritical CO(2) pressurization, by means of differential scanning calorimetry (DSC) and X-ray diffraction (XRD), are presented in this work. These include (1) the DSC heating curve of pure CBU; (2) the DSC heating curves of CBU/CBE mixtures; (3) the XRD spectra of pure CBU; (4) the XRD spectra of CBU/CBE mixtures; (5) CBU and CBE are miscible in either solid phase or liquid phase over the whole composition range. As a result of the presence of these phase transformations induced by pressurization, it could be deduced that a solid solution of the CBU/CBE mixture might have formed at the interfaces under supercritical conditions, subsequently influencing their dissolving behaviors in supercritical CO(2).Copyright 2010 Elsevier B.V. All rights reserved.