Development of the Suzuki-Miyaura cross-coupling reaction: Use of air-stable potassium alkynyltrifluoroborates in aryl alkynylations

…, BW Katona, F Machrouhi

Index: Molander, Gary A.; Katona, Bryson W.; Machrouhi, Fouzia Journal of Organic Chemistry, 2002 , vol. 67, # 24 p. 8416 - 8423

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Citation Number: 212

Abstract

The palladium-catalyzed cross-coupling reaction of potassium alkynyltrifluoroborates with aryl halides or triflates proceeds readily with moderate to excellent yields. The potassium alkynyltrifluoroborates are air-and moisture-stable crystalline solids that can be stored indefinitely, which will provide an advantage in applications to combinatorial chemistry. The alkynyl cross-coupling reaction can be effected using 9 mol% of PdCl2 (dppf)⊙ CH2Cl2 ...

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