Journal of Heterocyclic Chemistry

Preparation of some 4??hydroxyl??1??methyl??1H??2, 1??benzothiazine??3??carboxanilide 2, 2??dioxides

JG Lombardino

Index: Lombardino,J.G. et al. Journal of Heterocyclic Chemistry, 1972 , vol. 9, p. 315 - 317

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Citation Number: 26

Abstract

Abstract An improved, 3-step synthesis of 3, 4-dihydro-1-methyl-1H-2, 1-benzothiazin-4-one 2, 2-dioxide has been developed. This general method offers a more facile entrance into the 2, 1-benzothiazine 2, 2-dioxide heterocyclic system than was heretofore available. Preparation of several 3-carbox-anilides was accomplished by interaction of this ring system with various isocyanates. The resulting carboxanilides are moderately strong, enolic acids.

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