Organic Letters 2010-09-17

1,1-Dibromo-1-alkenes as valuable partners in the copper-catalyzed direct alkynylation of azoles.

Beatriz Pacheco Berciano, Sabrina Lebrequier, François Besselièvre, Sandrine Piguel

Index: Org. Lett. 12 , 4038, (2010)

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Abstract

The copper-catalyzed direct alkynylation of azoles with 1,1-dibromo-1-alkenes as electrophiles is described. These easily accessible substrates are a useful addition to the field of direct alkynylations in an efficient and functional group tolerant reaction to provide a straightforward entry to diverse alkynyl heterocycles.

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  • Copper(I) bromide...

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