Bioorganic & Medicinal Chemistry Letters 2007-06-15

Synthesis and cytotoxic activity of trisubstituted-1,3,5-triazines.

Kapil Arya, Anshu Dandia

Index: Bioorg. Med. Chem. Lett. 17 , 3298-304, (2007)

Full Text: HTML

Abstract

1,3,5-Triazine derivatives were screened for phototoxicity as well as the cytotoxic activities against leukemia and adenocarcinoma derived cell lines in comparison to the normal human keratinocytes. A simple and environmentally friendly procedure has been developed for the synthesis of 1,3,5-triazine derivatives under microwave irradiation in the presence of a HY zeolite. The catalyst can be recovered and reused. Thus, the procedure provides a simple and green synthetic methodology under environmentally friendly conditions. Structure-activity relationships between the chemical structures and antimycobacterial and photosynthesis-inhibiting activity of the evaluated compounds are also discussed.

Related Compounds

  • Rifampicin
  • Diuron
  • Altretamine

Related Articles:

Enhancement of in vitro activity of tuberculosis drugs by addition of thioridazine is not reflected by improved in vivo therapeutic efficacy.

2014-12-01

[Tuberculosis (Edinb.) 94(6) , 701-7, (2015)]

Disruption of an M. tuberculosis membrane protein causes a magnesium-dependent cell division defect and failure to persist in mice.

2015-02-01

[PLoS Pathog. 11(2) , e1004645, (2015)]

Kinetics of recA and recX induction in drug-susceptible and MDR clinical strains of Mycobacterium tuberculosis.

2014-12-01

[J. Antimicrob. Chemother. 69(12) , 3199-202, (2014)]

A trisubstituted benzimidazole cell division inhibitor with efficacy against Mycobacterium tuberculosis.

2014-01-01

[PLoS ONE 9(4) , e93953, (2014)]

Desmethyl bosentan displays a similar in vitro interaction profile as bosentan.

2015-02-01

[Pulm. Pharmacol. Ther. 30 , 80-6, (2015)]

More Articles...