European Journal of Medicinal Chemistry 2011-04-01

Synthesis and biological activity of 2-(bis((1,3,4-oxadiazolyl/1,3,4-thiadiazolyl)methylthio)methylene)malononitriles.

V Padmavathi, G Dinneswara Reddy, S Nagi Reddy, K Mahesh

Index: Eur. J. Med. Chem. 46 , 1367-73, (2011)

Full Text: HTML

Abstract

The reactivity of ketene dithiolates in the presence of different equivalents of sodium ethoxide was studied. 2-(Bis((5-aryl-1,3,4-oxadiazol-2-yl)methylthio)methylene)malononitriles 5 and 2-(bis((5-aryl-1,3,4-thiadiazol-2-yl)methylthio)methylene)malononitriles 6 were prepared by the reaction of malononitrile with carbon disulfide and 5-aryl-2-(chloromethyl)-1,3,4-oxadiazoles 3/5-aryl-2-(chloromethyl)-1,3,4-thiadiazoles 4. The preliminary antimicrobial and antioxidant activities of the lead compounds were assayed.Copyright © 2011 Elsevier Masson SAS. All rights reserved.

Related Compounds

  • Ascorbic acid
  • Malononitrile
  • Ketoconazole

Related Articles:

Comparative in vitro study on magnetic iron oxide nanoparticles for MRI tracking of adipose tissue-derived progenitor cells.

2014-01-01

[PLoS ONE 9(9) , e108055, (2014)]

DNA double-strand breaks by Cr(VI) are targeted to euchromatin and cause ATR-dependent phosphorylation of histone H2AX and its ubiquitination.

2015-01-01

[Toxicol. Sci. 143(1) , 54-63, (2014)]

Hypoxia reduces MAX expression in endothelial cells by unproductive splicing.

2014-12-20

[FEBS Lett. 588(24) , 4784-90, (2014)]

Proteolysis of decellularized extracellular matrices results in loss of fibronectin and cell binding activity.

2015-04-03

[Biochem. Biophys. Res. Commun. 459(2) , 246-51, (2015)]

Flow perfusion co-culture of human mesenchymal stem cells and endothelial cells on biodegradable polymer scaffolds.

2014-07-01

[Ann. Biomed. Eng. 42(7) , 1381-90, (2014)]

More Articles...