Synthesis

Novel, one-pot procedure for the synthesis of 2-arylethanol derivatives

T Schläger, C Oberdorf, B Tewes, B Wuensch

Index: Schlaeger, Torsten; Oberdorf, Christoph; Tewes, Bastian; Wuensch, Bernhard Synthesis, 2008 , # 11 p. 1793 - 1797

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Abstract

Abstract An efficient one-pot synthesis of 2-arylethanol derivatives using ethylene sulfate as a C 2 building block is described. High yields are obtained upon trapping of aryllithium intermediates generated by halogen-metal exchange or directed metalation with ethylene sulfate. The resulting heteroaryl or phenylethanol derivatives represent versatile building blocks for the synthesis of annulated pyran derivatives by oxa-Pictet-Spengler reaction.

2-Substituted (2 SR)-2-amino-2-((1 SR, 2 SR)-2-carboxycycloprop-1-yl) glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 2. …

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Simple Reduction of Heteroaromatic Esters to Alcohols Using a Sodium Borohydride–Methanol System

Investigation of the aroma-active compounds formed in the Maillard reaction between glutathione and reducing sugars

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Novel, one-pot procedure for the synthesis of 2-arylethanol derivatives

Abstract

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