Pathology - Research and Practice 2014-12-01

A new pathological scoring method for adrenal injury in rats with severe acute pancreatitis.

Wenhong Deng, Yuanjian Hui, Jia Yu, Weixing Wang, Sheng Xu, Chen Chen, Xincheng Xiong

Index: Pathol. Res. Pract. 210(12) , 1011-7, (2014)

Full Text: HTML

Abstract

These studies investigated the appearance and function of adrenal glands in rats with severe acute pancreatitis (SAP) and established a new histopathological score to evaluate adrenal histopathological changes. Severe acute pancreatitis relied on retrograde infusion of 5% sodium taurocholate into the bile-pancreatic duct. The damage of SAP was estimated by serum amylase, secretory phospholipase A2 and pancreatic histopathology. Light and electron microscopy of adrenal gland, and the levels of serum corticosterone were investigated. These results showed that the generally ascending trend of adrenal pathological score was inversely proportional to the generally descending trend of serum corticosterone levels, but parallel with the changes of pancreatic histopathology. Herein, the new adrenal histopathological score was effective in the evaluation of adrenal injury following SAP. It may indirectly reflect the variation of serum cortisol levels and the severity of pancreatitis to a certain extent. Copyright © 2014. Published by Elsevier GmbH.

Related Compounds

  • Sodium taurocholat...
  • glutaraldehyde
  • Tetrachlorosilane

Related Articles:

Sensing of triacylglycerol in the gut: different mechanisms for fatty acids and 2-monoacylglycerol.

2015-04-15

[J. Physiol. 593(8) , 2097-109, (2015)]

Solid lipid particles for oral delivery of peptide and protein drugs III - the effect of fed state conditions on the in vitro release and degradation of desmopressin.

2014-07-01

[AAPS J. 16(4) , 875-83, (2014)]

Identification of a novel hypocholesterolemic protein, major royal jelly protein 1, derived from royal jelly.

2014-01-01

[PLoS ONE 9(8) , e105073, (2014)]

Pancreatic ascites hemoglobin contributes to the systemic response in acute pancreatitis.

2015-04-01

[Free Radic. Biol. Med. 81 , 145-55, (2015)]

High-resolution mass spectrometry associated with data mining tools for the detection of pollutants and chemical characterization of honey samples.

2014-11-19

[J. Agric. Food Chem. 62(46) , 11335-45, (2014)]

More Articles...