Potent, selective, and orally bioavailable matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis

…, J Schmid, JS Skotnicki, S Tam, JR Thomason…

Index: Hu, Yonghan; Xiang, Jason S.; DiGrandi, Martin J.; Du, Xuemei; Ipek, Manus; Laakso, Leif M.; Li, Jianchang; Li, Wei; Rush, Thomas S.; Schmid, Jean; Skotnicki, Jerauld S.; Tam, Steve; Thomason, Jennifer R.; Wang, Qin; Levin, Jeremy I. Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 24 p. 6629 - 6644

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Citation Number: 68

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... Modification of α-biphenylsulfonamidocarboxylic acids led to potent and selective MMP-13 inhibitors. Compound 16 showed 100% oral bioavailability in rats and demonstrated >50% inhibition of bovine cartilage degradation at 10 ng/mL. ... Modification of α-biphenylsulfonamidocarboxylic acids led to ...