Synthetic Communications®

Methanesulfonic acid/SiO2 as an efficient combination for the synthesis of 2-substituted aromatic and aliphatic benzothiazoles from carboxylic acids

H Sharghi, O Asemani

Index: Sharghi, Hashem; Asemani, Omid Synthetic Communications, 2009 , vol. 39, # 5 p. 860 - 867

Full Text: HTML

Citation Number: 49

Abstract

Abstract Methanesulfonic acid/SiO2 (1 mL/0.3 g) was found to be as an expeditious mixture in the synthesis of 2-substituted aromatic and aliphatic benzothiazoles at 140° C using carboxylic acids. After a simple workup, benzothiazoles were obtained in good yields. Simplicity, use of widely available and diverse carboxylic acids, and easy handling of the reaction conditions are among the benefits of the method.

Related Articles:

Structure–activity relationship studies of SYA 013, a homopiperazine analog of haloperidol

[Peprah, Kwakye; Zhu, Xue Y.; Eyunni, Suresh V.K.; Etukala, Jagan R.; Setola, Vincent; Roth, Bryan L.; Ablordeppey, Seth Y. Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 5 p. 1671 - 1678]

Tuning the optical and electronic properties of 4, 8-disubstituted benzobisoxazoles via alkyne substitution

[Mylari, Banavara L.; Scott, Pamela J.; Zembrowski, William J. Synthetic Communications, 1989 , vol. 19, # 16 p. 2921 - 2924]

Self-condensation of benzothiazolylchloromethyllithiums

[Florio, Saverio; Capriati, Vito; Solimini, Maria Cristina; Troisi, Luigino Tetrahedron Letters, 1994 , vol. 35, # 45 p. 8481 - 8484]

More Articles...