Fortschritte der Medizin 1995-03-20

[Therapy of rheumatic disease with a hydroxyethylsalicylate gel. Results of 2 clinical studies of effectiveness and bioavailability].

M Rutner, J Fitzek, H Jahnel-Kracht, J Otto, W Krause

Index: Fortschr. Med. 113(8) , 111-3, (1995)

Full Text: HTML

Abstract

Two clinical studies were carried out to investigate the efficacy and safety as well as the local and systemic availability of a hydroxyethylsalicyclate gel. A double blind, multicenter trial, involving 113 patients with nonarticular rheumatic back pain, revealed statistically significant relief of pain as compared with placebo. Local and systemic tolerance was excellent. An open study of bioavailability after local application in 16 patients showed a mean salicylate concentration of 0.93 +/- 0.5 microgram/ml in the synovial fluid and 0.40 +/- 0.23 microgram/ml in the synovial membrane, compared with 0.14 +/- 0.04 microgram/ml in the serum. Genetisinic acid was not detected, while OH-hippuric acid was detected only in the serum and synovial fluid.

Related Compounds

  • Salicylic acid
  • Hippuric acid
  • 2-Hydroxyethyl sal...

Related Articles:

Inhibition of aberrant complement activation by a dimer of acetylsalicylic acid.

2015-10-01

[Neurobiol. Aging 36 , 2748-56, (2015)]

Graphene modified glassy carbon sensor for the determination of aspirin metabolites in human biological samples.

2015-10-01

[Talanta 143 , 328-34, (2015)]

Safety and biocompatibility of carbohydrate-functionalized polyanhydride nanoparticles.

2015-01-01

[AAPS J. 17(1) , 256-67, (2015)]

Hemagglutinin-based polyanhydride nanovaccines against H5N1 influenza elicit protective virus neutralizing titers and cell-mediated immunity.

2015-01-01

[Int. J. Nanomedicine 10 , 229-43, (2015)]

Polyanhydride Nanoparticle Delivery Platform Dramatically Enhances Killing of Filarial Worms.

2015-01-01

[PLoS Negl. Trop. Dis. 9 , e0004173, (2015)]

More Articles...