Chemistry: A European Journal 2013-01-14

Preparation of functionalized organoindium reagents by means of magnesium insertion into organic halides in the presence of InCl3 at room temperature.

Sebastian Bernhardt, Zhi-Liang Shen, Paul Knochel

Index: Chemistry 19(3) , 828-33, (2013)

Full Text: HTML

Abstract

Magnesium, indium, palladium: An efficient one-pot procedure for the direct preparation of triorganoindium reagents from organic halides by means of magnesium insertion in the presence of InCl(3) and LiCl is reported (see scheme). The organoindium reagents are obtained in good yields from functionalized aryl, heteroaryl, and alkyl bromides and benzyl chlorides at 25 °C in THF within 4 h. Moreover, the resulting organoindium reagents could be efficiently used as reagents in Pd-catalyzed cross-coupling reactions with a wide functional group tolerance.Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Related Compounds

  • Indium chloride

Related Articles:

Synthesis of CuInSe(2) nanocrystals with trigonal pyramidal shape.

2009-03-11

[J. Am. Chem. Soc. 131(9) , 3134-5, (2009)]

Pleural effects of indium phosphide in B6C3F1 mice: nonfibrous particulate induced pleural fibrosis.

2009-12-01

[Exp. Lung Res. 35(10) , 858-82, (2009)]

InCl3 mediated one-pot multicomponent synthesis, anti-microbial, antioxidant and anticancer evaluation of 3-pyranyl indole derivatives.

2010-09-01

[Bioorg. Med. Chem. Lett. 20 , 5054-61, (2010)]

InCl(3)-catalyzed asymmetric aza-Friedel-Crafts reaction of indoles with imines generated from O-pivaloylated beta-D-galactosylamine.

2010-08-16

[Carbohydr. Res. 345 , 1708-1712, (2010)]

Synthesis of gamma-amino esters via Mn-mediated radical addition to chiral gamma-hydrazonoesters.

2009-03-05

[Org. Lett. 11(5) , 1095-8, (2009)]

More Articles...