Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 2012-01-01

[Study on the bioactive constituents of Piper wallichii].

Guo-Wei Zhao, Wen Xia, Ping Chen, En-Ji Han, Lan Xiang

Index: Zhong Yao Cai 35(1) , 53-6, (2012)

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Abstract

To investigate the bioactive constituents in the stem of Piper wallichii.Compounds were separated by column chromatography of silica gel, ODS-A and Sephadex LH-20. Their structures were elucidated based on spectral analysis. DPPH scavenging activity and AchE inhibitory activity were tested.10 compounds were isolated and their structures were identified as 3,4-methylenedioxy-benzoic acid (1), vanillic acid (2), benzoic acid (3), N-p-coumaroyltyramine (4), futoenone (5), futoquinol (6), isofutoquinol A (7), 4-hydroxy-3,5-dimethoxy-benzoic acid (8), futoamide (9), dihydropiperlonguminine (10).Compounds 1-6 are isolated from P. wallichii for the first time. Vanillic acid (2) and 4-hydroxy-3,5-dimethoxy-benzoic acid (8) show scavenging activity against DPPH radical with ED50 at 224.33 microg/mL and 11.44 microg/mL, respectively. No compound shows inhibition activity against AchE.

Related Compounds

  • Vanillic acid
  • Heliotropic acid

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