The Journal of Organic Chemistry

Cobalt (II) chloride catalyzed acylation of alcohols with acetic anhydride: scope and mechanism

J Iqbal, RR Srivastava

Index: Iqbal, Javed; Srivastava, Rajiv Ranjan Journal of Organic Chemistry, 1992 , vol. 57, # 7 p. 2001 - 2007

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Citation Number: 229

Abstract

Cobalt (I1) chloride catalyzes the acetylation of a variety of alcohols with acetic anhydride in excellent yield. Primary hydroxyl groups can be selectively acylated in the presence of secondary and tertiary ones while the secondary hydroxyl groups can be preferentially acetylated in the presence of tertiary ones. Tertiary alcohols have been found to give ketones, acetoacetates, olefins, and diketene in addition to the acetate. The &hydroxy ...

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