Natural Product Research 2006-10-01

Oxidation studies on Andrographolide.

Vijayavitthal T Mathad, Satish Kumar, Kanwal Raj

Index: Nat. Prod. Res. 20(12) , 1053-8, (2006)

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Abstract

Jones oxidation of Andrographolide (1), gave mixture of three products (3-dehydroandrographolide (5), 3,19-bis dehydroandrographolide (6) and 19-dehydroandrographolide (7). Tritylation of andrographolide at C19-OH resulted to products 8 and diene 9, which can be converted to its acetate 10 and oxidation product 11.

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