New technique for high-throughput synthesis.

M Lebl

Index: Bioorg. Med. Chem. Lett. 9(9) , 1305-10, (1999)

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Abstract

A new technique for high throughput solid phase synthesis using the centrifuge based liquid removal from readily available standard microtiterplates is described. This technique eliminates the filtration step and is therefore applicable to simultaneous processing of an unlimited number of reaction compartments. Its application is illustrated on the synthesis of an array of 380 tetrahydroisoquinolinones.