An inhibitor of CCL2-induced chemotaxis from the fungus Leptoxyphium sp.

P Klausmeyer, OMZ Howard, SM Shipley…

Index: Klausmeyer, Paul; Howard, O. M. Zack; Shipley, Suzanne M.; McCloud, Thomas G. Journal of Natural Products, 2009 , vol. 72, # 8 p. 1369 - 1372

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Citation Number: 8

Abstract

A biological screen used to identify inhibitors of monocyte chemotactic protein-1 (CCL2)- induced chemotaxis was applied in the activity-guided fractionation of an extract from a fungus of the genus Leptoxyphium sp. Inhibition of CCL2-induced chemotaxis was traced to a new dichlorinated diketopiperazine, cyclo (13, 15-dichloro-l-Pro-l-Tyr). A structure− activity relationship (SAR) study evaluating relative activities of cyclo (13, 15-dichloro-l-Pro-l-Tyr) ...