Occupational hazard evaluation of p-bromobenzyl bromide from tests for genotoxicity.

E V Sargent, J F Sina, J E Barnum, R D Storer, T E Johnson, S M Galloway, M G Prato, N N Kirsten, B D Naumann

Index: Drug Chem. Toxicol. 22(4) , 583-93, (1999)

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Abstract

As part of an occupational hazard evaluation, p-bromobenzyl bromide (p-BBB) was evaluated for genotoxic activity in the Ames microbial mutagenicity assay, the alkaline elution assay for DNA strand breaks in rat hepatocytes and the in vitro chromosome aberration assay in Chinese hamster ovary cells. The compound produced equivocal results in the microbial mutagenicity assay but was negative in the alkaline elution assay for DNA strand breaks in rat hepatocytes. The compound produced weakly positive results in the in vitro chromosome aberration assay. There was substantial cytotoxicity in all three assays. It is concluded that p-BBB is weakly genotoxic.