Molecular Diversity 2012-08-01

An efficient three-component, one-pot synthesis of 2-alkylthio-4-amino-5-cyano-6-aryl(alkyl)pyrimidines in water.

Qiao-Yan Li, Ze-Mei Ge, Tie-Ming Cheng, Run-Tao Li

Index: Mol. Divers. 16(3) , 431-9, (2012)

Full Text: HTML

Abstract

A convenient and practical method for the synthesis of 2-alkylthio-4-amino-5-cyano-6-aryl(alkyl)pyrimidines has been developed via a three-component, one-pot reaction from aldehydes, malononitrile and S-alkylisothiouronium salts in water at room temperature. A series of polysubstituted pyrimidines were prepared by this method in moderate to excellent yields. In addition, two kinds of pyrimidine-fused heterocyclic derivatives with potential pharmacological activity were constructed from our 2-alkylthio-4-amino-5-cyano-6-arylpyrimidines.

Related Compounds

  • Malononitrile

Related Articles:

Synthesis of a novel 4H-pyran analog as minor groove binder to DNA using ethidium bromide as fluorescence probe.

2016-01-05

[Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 152 , 165-71, (2015)]

Design of donor-acceptor star-shaped oligomers for efficient solution-processible organic photovoltaics.

2014-01-01

[Faraday Discuss. 174 , 313-39, (2014)]

A facile synthesis of new monoazo disperse dyes derived from 4-hydroxyphenylazopyrazole-5-amines: evaluation of microwave assisted dyeing behavior.

2012-01-01

[Molecules 17(12) , 13891-909, (2012)]

Structure-activity relationships of a novel pyranopyridine series of Gram-negative bacterial efflux pump inhibitors.

2015-05-01

[Bioorg. Med. Chem. 23(9) , 2024-34, (2015)]

Synthesis of 2-arylamino substituted 5,6-dihydropyrido[2,3-d]pyrimidine-7(8H)-ones from arylguanidines.

2012-11-01

[Mol. Divers. 16(4) , 639-49, (2012)]

More Articles...