Nature Protocols 2007-01-01

Practical and convenient synthesis of coumarins from phenols and propiolic acid esters.

Tsugio Kitamura, Juzo Oyamada, Toshiyuki Tsubota

Index: Nat. Protoc. 2(4) , 845-8, (2007)

Full Text: HTML

Abstract

This protocol describes the synthesis of 6,7-methylenedioxy-4-phenylcoumarin from sesamol and ethyl phenylpropiolate using a Pd(OAc)2 catalyst to illustrate coumarin synthesis. This procedure is simple and easy and can be applied to the synthesis of other coumarins that have electron-rich phenol groups. The reaction is conducted by stirring a solution of Pd(OAc)2, sesamol and ethyl phenylpropiolate in trifluoroacetic acid at room temperature (15-20 degrees C) under atmospheric conditions. This protocol can be completed in 3 d.

Related Compounds

  • Ethyl 3-phenyl-2-p...

Related Articles:

Overexpression of three ubiquitin genes in mouse epidermal tumors is associated with enhanced cellular proliferation and stress.

1992-05-01

[Cell Growth Differ. 3(5) , 269-78, (1992)]

Changes in cytokeratins following treatment of hamster cheek pouch epithelia with hyperplastic or neoplastic agents.

1994-04-01

[J. Oral. Pathol. Med. 23(4) , 149-55, (1994)]

Benzoyl peroxide activation of protein kinase C activity in epidermal cell membranes.

1987-12-01

[Carcinogenesis 8(12) , 1871-4, (1987)]

Induction of ornithine decarboxylase in specific subpopulations of murine epidermal cells following multiple exposures to 12-O-tetradecanoylphorbol-13-acetate, mezerein and ethyl phenylpropriolate.

1992-01-01

[Carcinogenesis 13(1) , 51-6, (1992)]

Non-promoting hyperplasiogenic agents do not mimic the effects of phorbol, 12-myristate, 13-acetate on terminal differentiation of normal and transformed human keratinocytes.

1984-05-01

[Carcinogenesis 5(5) , 687-90, (1984)]

More Articles...