Synthesis of tetrakis (multifluoro-4-pyridyl) porphin derivatives as acetylcholinesterase inhibitors

…, HS Kim, BS Yu, JS Lee, BS Lee, SK Namgoong

Index: Moon, Sin Chul; Shin, Jung-Hyu; Jeong, Bong Ho; Kim, Hee Seok; Yu, Byung Soo; Lee, Ji-Sook; Lee, Bang Sook; Namgoong, Sung Keon Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 13 p. 1435 - 1438

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Citation Number: 14

Abstract

New tetrakis (multifluoro-4-pyridyl) porphin derivatives (2–4) and water soluble porphyrin (5) were synthesized to investigate their interactions with acetylcholinesterase from electric eel. These compounds have been found to be the potent reversible inhibitors of the enzyme with Ki values of μM range. In addition, porphyrin (5) showed broad spectrum of anticancer activities.