Vasa 2014-01-01

Tanshinone IIA attenuates elastase-induced AAA in rats via inhibition of MyD88-dependent TLR-4 signaling.

Tao Shang, Feng Ran, Qian Qiao, Zhao Liu, Chang-Jian Liu

Index: VASA 43(1) , 39-46, (2014)

Full Text: HTML

Abstract

The purpose of this study was to determine whether myeloid differentiation factor88-dependent Toll-Like Receptor-4 (TLR-4) signaling contributed to the inhibition of abdominal aortic aneurysm (AAA) by Tanshinone IIA (Tan IIA).Male Sprague-Dawley rats (n = 12 / group) were randomly distributed into three groups: Tan IIA, control, and sham. The rats from Tan IIA and control groups under-went intra-aortic elastase perfusion to induce AAAs, and those in the sham group were perfused with saline. Only the Tan IIA group received Tan IIA (2 mg / rat / d). Aortic tissue samples were harvested at 24 d after perfusion and evaluated using reverse transcriptase-polymerase chain reaction, Western blot, immunohistochemistry and immunofluorescence.The over-expression of Toll-Like Receptor-4 (TLR-4), Myeloid Differentiation factor 88 (MyD88), Phosphorylated Nuclear Factor κB (pNF-κB) and Phosphorylated IκBα (pIκBα) induced by elastase perfusion were significantly decreased by Tan IIA treatment.Tan IIA attenuates elastase-induced AAA in rats possibly via the inhibition of MyD88-dependent TLR-4 signaling, which may be one potential explanation of why Tan IIA inhibits AAA development through multiple effects.

Related Compounds

  • Elastase from porc...
  • Tanshinone IIA
  • Tanshinone I

Related Articles:

Targeting latent TGFβ release in muscular dystrophy.

2014-10-22

[Sci. Transl. Med. 6(259) , 259ra144, (2014)]

Can we predict postoperative pancreatic leakage after pancreaticoduodenectomy using preoperative fecal elastase-1 level?

2013-09-01

[J. Clin. Lab Anal. 27(5) , 379-83, (2013)]

Collagenase mRNA Overexpression and Decreased Extracellular Matrix Components Are Early Events in the Pathogenesis of Emphysema.

2015-01-01

[PLoS ONE 10 , e0129590, (2015)]

Tumor necrosis factor-like weak inducer of apoptosis or Fn14 deficiency reduce elastase perfusion-induced aortic abdominal aneurysm in mice.

2014-08-01

[J. Am. Heart Assoc. 3(4) , doi:10.1161/JAHA.113.000723, (2014)]

[Hydrolytic activity of microorganisms of the Dead Sea coastal ecosystems].

2014-01-01

[Mikrobiol. Z. 76(1) , 16-20, (2014)]

More Articles...