Brain Research 1986-06-11

Inhibition by neosurugatoxin of nicotine-induced antinociception.

S Yamada, Y Kagawa, N Takayanagi, E Hayashi, K Tsuji, T Kosuge

Index: Brain Res. 375(2) , 360-2, (1986)

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Abstract

We have found a selective inhibition of nicotine-induced antinociception in mice by neosurugatoxin (NSTX, 0.4-3.8 nmol/kg), a neurotoxin with a high affinity for ganglionic nicotinic receptors (ED50 = 0.65 nmol/kg). The toxin also reduced specific [3H]nicotine binding in mouse brain membranes (IC50 = 95 nM). The anti-nicotinic activity of NSTX was markedly greater than that of mecamylamine and pempidine. These data indicate that NSTX may block functional nicotinic cholinoceptors possibly in the central nervous system.

Related Compounds

  • Pempidine

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