General Pharmacology: The Vascular System 1997-07-01

Nicotinic antagonists (piperidines and quinuclidines) reduce the susceptibility of early sea urchin embryos to agents evoking calcium shock.

G A Buznikov, L N Koikov, Shmukler YuB, M J Whitaker

Index: Gen. Pharmacol. 29(1) , 49-53, (1997)

Full Text: HTML

Abstract

1. Some nicotinic antagonists (piperidine and quinuclidine derivatives and bis-quaternary compounds) protect early embryos of the sea urchin Lytechinus pictus against a calcium shock evoked by ionomycin or a mixture of phorbol myristate acetate and nicotine. 2. Maximal protective potency was found for drugs that did not penetrate the plasma membrane. 3. Early sea urchin embryos have nicotinic acetylcholine receptors (nAChR) or nAChR-like structures localized on the cell surface that, apparently, take part in the control of Ca2+ influx.

Related Compounds

  • Pempidine
  • 1,2,2,6,6-pentamet...

Related Articles:

Pharmacological characterization of a nicotinic autoreceptor in rat hippocampal synaptosomes.

1996-09-01

[Neurochem. Res. 21(9) , 1141-8, (1996)]

Enhancement of naturally occurring cell death in the sympathetic and parasympathetic ganglia of the chicken embryo following blockade of ganglionic transmission.

1988-03-15

[Brain Res. 444(1) , 189-94, (1988)]

Understanding channel blocking in the nicotinic acetylcholine receptor.

2001-01-01

[Receptors Channels 7(4) , 273-88, (2001)]

Functional heterogeneity of the matrix compartment in the cat caudate nucleus as demonstrated by the cholinergic presynaptic regulation of dopamine release.

1992-10-01

[Neuroscience 50(3) , 597-610, (1992)]

[Effect of pyrilene and temechin on central and pulmonary hemodynamics in the treatment of hemoptysis].

1988-06-01

[Vrach. Delo (6) , 47-9, (1988)]

More Articles...