An Approach to the Site??Selective Deoxygenation of Hydroxy Groups Based on Catalytic Phosphoramidite Transfer

PA Jordan, SJ Miller

Index: Jordan, Peter A.; Miller, Scott J. Angewandte Chemie - International Edition, 2012 , vol. 51, # 12 p. 2907 - 2911

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Citation Number: 35

Abstract

The site-selective, catalytic modification of complex molecules is a long-standing goal for chemists. Given the high efficiency of many fermentation processes, the use of natural products as scaffolds for diversification is part of many epic drug-discovery programs.[1] Yet, it is generally accepted that these research efforts are challenging, often requiring multistep syntheses of the requisite analogues,[2] re-engineered biosynthetic pathways,[3] or ...