Revisiting the Hirao cross-coupling: improved synthesis of aryl and heteroaryl phosphonates

Y Belabassi, S Alzghari, JL Montchamp

Index: Belabassi, Yamina; Alzghari, Saeed; Montchamp, Jean-Luc Journal of Organometallic Chemistry, 2008 , vol. 693, # 19 p. 3171 - 3178

Full Text: HTML

Citation Number: 88

Abstract

The palladium-catalyzed cross-coupling of dialkylphosphite with aromatic electrophiles (Hirao coupling) was re-investigated. Some limitations in terms of palladium loadings and substrate reactivity are alleviated with the use of Pd (OAc) 2 complexed to 1, 1′-bis (diphenylphosphino) ferrocene (dppf) as a ligand. Various aryl and heteroaryl halides are employed to deliver both known and novel substituted phosphonates. The first examples ...