Bioorganic & Medicinal Chemistry Letters 2006-08-15

Biomolecular sensor based on fluorescence-labeled aptamer.

Hiroaki Ozaki, Akifumi Nishihira, Masayuki Wakabayashi, Masayasu Kuwahara, Hiroaki Sawai

Index: Bioorg. Med. Chem. Lett. 16(16) , 4381-4, (2006)

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Abstract

Fluorescent DNA probes for L-argininamide were developed by a combination of DNA aptamers and fluorophore-quencher pairs. These molecules were synthesized by a combination of pre- and post-synthetic modification methods. The fluorescence-labeled aptamer could detect L-argininamide specifically. The binding affinities were defined by the binding affinity of the original aptamer to indicate that the end labeling of the aptamer did not influence the affinities.

Related Compounds

  • H-Arg-NH2.2HCl

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