Synthesis and anti-inflammatory activity of some 3-(4, 6-disubtituted-2-thioxo-1, 2, 3, 4-tetrahydropyrimidin-5-yl) propanoic acid derivatives

…, SS Shinde, RD Elgire, JN Sangshetti…

Index: Mokale, Santosh N.; Shinde, Sandeep S.; Elgire, Rupali D.; Sangshetti, Jaiprakash N.; Shinde, Devanand B. Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 15 p. 4424 - 4426

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Citation Number: 34

Abstract

A series of 3-(4, 6-disubtituted-2-thioxo-1, 2, 3, 4-tetrahydropyrimidin-5-yl) propanoic acid derivatives has been synthesized by condensation of thiourea, 5-(4-subtituted phenyl)-5- oxopentanoic acid and substituted aldehyde. The synthesized compounds were screened for their anti-inflammatory activity using rat paw edema method. Most of the compounds from the series showed significant (p< 0.05) anti-inflammatory activity.