4'-O-Alkyaloenin derivatives and their sulfates directed toward overcoming multidrug resistance in tumor cells.
Guang-Zhu Jin, Hong-Ji Quan, Jyunichi Koyanagi, Kazuhiro Takeuchi, Yoshihiko Miura, Fusao Komada, Setsuo Saito
Index: Cancer Lett. 218(1) , 15-20, (2005)
Full Text: HTML
Abstract
The cytotoxic effects on HCT 116, Hep G2 and HCT 116/VCR 100-1-1 cell lines of synthetic 4'-O-alkylaloenins (2-17), 4'-O-benzylaloenin (18) and 4'-O-allylaloenin (19) were examined by MTT assay, and compared with that of aloenin (1) isolated from Aloe arborescens Mill. Var. natalensis Berger which showed no marked effect (IC50 value: > 100 microM). The cytotoxic effects of 4'-O-alkylaloenin sulfates (21-29) were also examined on the same cell lines. The introduction of a longer alkyl group at the O-4' position of 1 resulted in a higher cytotoxic action on HCT 116 and Hep G2 cells. Among 4'-O-alkylaloenins 2-17, 4'-O-tetradecylaloenin 14 was the most cytotoxic to both on HCT 116 cells (IC50 value: 5.3+/-2.3 microM) and Hep G2 cells (IC50 value: 4.0+/-0.6 microM). Also among 4'-O-alkylaloenin sulfates 21-29, 4'-O-dodecylaloenin sulfate 29 was the most cytotoxic to both on HCT 116 (IC50 value: 4.8+/-0.2 microM) and Hep G2 cells (IC50 value: 4.0+/-0.5 microM). 4'-O-Alkylaloenins 7-14 and 4'-O-alkylaloenin sulfates 24-29 were also cytotoxic to Hep G2 and HCT 116/VCR 100-1-1 cell lines, which overexpress P-glycoprotein, as well as HCT 116 cell lines which scarcely express it.
Related Compounds
Related Articles:
2008-10-01
[J. Nat. Med. 62(4) , 430-5, (2008)]
2001-03-05
[J. Chromatogr. B. Biomed. Sci. Appl. 752(1) , 91-7, (2001)]
2006-02-20
[J. Ethnopharmacol. 103(3) , 468-77, (2006)]
2009-01-01
[Nat. Prod. Res. 23 , 1035-1049, (2009)]
2002-11-01
[Ying Yong Sheng Tai Xue Bao 13(11) , 1381-4, (2002)]