Tetrahedron Letters

A synthesis of the γ-secretase inhibitor BMS-708163

GM Maharvi, AH Fauq

Index: Maharvi, Ghulam M.; Fauq, Abdul H. Tetrahedron Letters, 2010 , vol. 51, # 50 p. 6542 - 6544

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Citation Number: 7

Abstract

A concise, convergent racemic synthesis of BMS-708163 is reported. Two fragments consisting of N-4-chlorophenylsulfonyl-3, 3, 3-trifluorpropylglycine and a 1, 2, 4-oxadiazole derivative of 2-fluorobenzyl alcohol were prepared in separate pots and then coupled together via a Mitsunobu reaction. Since a convenient chiral synthesis of optically pure (d)-3, 3, 3-trifluoropropyl glycine methyl ester was developed using Schöllkopf reagent ...