Anticancer Research 1994-01-01

A multiwell assay for inhibitors of phosphatidylinositol-3-kinase and the identification of natural product inhibitors.

T Frew, G Powis, M Berggren, R T Abraham, C L Ashendel, L H Zalkow, C Hudson, S Qazia, E Gruszecka-Kowalik, R Merriman

Index: Anticancer Res. 14(6B) , 2425-8, (1994)

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Abstract

A convenient and reliable multisample assay for the screening of inhibitors of the growth factor signalling enzyme phosphatidylinositol-3-kinase (PtdIns-3-K) has been developed. Four natural product inhibitors of Ptdlns-3-K have been identified with IC50 values for hypericin 0.18 microM, emodin 3.3 microM, asperuloside 2.0 microM and uttronin A 1.1 microM.

Related Compounds

  • Asperuloside
  • uttronin A

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