Stereochemical differentiation of cyclic glycols by ion-molecule reactions in a quadrupole mass spectrometer using dimethyl ether acetonitrile and 2-S-pyrrolidinemethanol

Mancel, Sellier

Index: Rapid Commun. Mass Spectrom. 14(2) , 80-5, (2000)

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Abstract

In this study, ion-molecule reactions using chemical ionization in the positive ion mode using dimethyl ether, acetonitrile and 2-S-pyrrolidinemethanol as reagent gases have been used to distinguish between cis- and trans-1,2-cyclopentanediol and cis- and trans-1,2-cyclohexanediol. In the gas phase, the stereospecific ion-molecule reaction gives characteristic ions and substantial differences are observed in their relative abundances from which the diastereoisomers of those cyclic glycols can be clearly differentiated. Copyright 2000 John Wiley & Sons, Ltd.