Journal of Applied Toxicology 1985-12-01

Effects of phthalic acid esters on drug metabolizing enzymes of rat liver.

R Gollamudi, W H Lawrence, R H Rao, J Autian

Index: J. Appl. Toxicol. 5(6) , 368-71, (1985)

Full Text: HTML

Abstract

Di(2-ethylhexyl)phthalate (DEHP) inhibited UDP-glucuronyltransferase activity of rat liver in vitro and in vivo. Diethyl phthalate and dimethoxyethyl phthalate also inhibited this enzyme in vitro. On the other hand, DEHP did not inhibit the activity of the cytosolic enzyme N-acetyltransferase; it also did not alter the levels of rat liver microsomal cytochrome P-450 in vitro. It is suggested that DEHP may alter the composition of microsomal phospholipids.

Related Compounds

  • Bis(2-methoxyethyl...

Related Articles:

Determination of Selected Phthalates by Gas Chromatography-Mass Spectrometry in Personal Perfumes.

2015-01-01

[J. Toxicol. Environ. Health A 78 , 1008-18, (2015)]

Teratogenicity of dimethoxyethyl phthalate and its metabolites methoxyethanol and methoxyacetic acid in the rat.

1985-08-01

[Teratology 32(1) , 25-31, (1985)]

Evaluation of a testicular sperm head counting technique using rats exposed to dimethoxyethyl phthalate (DMEP), glycerol alpha-monochlorohydrin (GMCH), epichlorohydrin (ECH), formaldehyde (FA), or methyl methanesulphonate (MMS).

1983-05-01

[Arch. Toxicol. 53(1) , 71-8, (1983)]

Effects of dimethoxyethyl phthalate, monomethoxyethyl phthalate, 2-methoxyethanol and methoxyacetic acid on post implantation rat embryos in culture.

1984-04-01

[Toxicol. Lett. 21(1) , 97-102, (1984)]

Di(2-ethylhexyl)phthalate induces hepatic tumorigenesis through a peroxisome proliferator-activated receptor alpha-independent pathway.

2007-05-01

[J. Occup. Health 49(3) , 172-82, (2007)]

More Articles...